SKiN-HUID

Programme 2014 - 2020 INTERREG V-A Belgium - The Netherlands (Vlaanderen - Nederland)

Date of latest update: 2022-08-25

Description

Description (EN):

Cancer is one of the most threatening diseases of this century, causing eight million deaths worldwide each year. Cancer's complexity means the disease can only be treated through innovation and translating knowledge into new medication. Under the direction of the University of Maastricht, the University of Antwerp, Basic Pharma Technologies, MosaMedix and VIB are seeking to meet the specific challenges of cancer. At Euregional PACT, a virtual research laboratory set up through the previous Interreg programme, a number of basic medical technologies have already been developed at academic level. One of those technologies is the Anx-A5-based platform for Target Drug Delivery. It involves targeted administration of medicines via electrical or hypothermic stimulation, which exerts stress on the cells. Advantages of this technique are the efficient, targeted coupling of toxic pharmaceutical quantities, but on the basis of reduced doses so that general side-effects remain limited and the patient's quality of life is maintained. The aim is to further expand this technology within SKiN-HUID into a therapy, through preclinical and clinical validation. A stimulation device with applicator will be developed that is to be used for preclinical validation of the treatment. The Annexine A5-ETA-based medicine is also being further developed to enable targeted, efficient administration by means of the device and the applicator.

Description (NL):

Achievements (EN):

Cancer is one of the most threatening diseases of this century with 8 million deaths every year. The complexity of cancer means that this disease can only be successfully treated by innovation and translation of knowledge into new medicines. Under the leadership of Maastricht University (UM), University of Antwerp (UA), Basic Pharma Technologies, MosaMedix and VIB strive to respond to the specific challenges of skin cancer. Euregional PACT, a virtual research laboratory created through the previous Interreg programme, has already developed a number of basic medical technologies at the academic level. One of these technologies is the Annexine-A5-based platform for Target Drug Delivery. It involves a targeted administration of medications via electrical or hyperthermal stimulation that puts stress on the cells. Benefits of this technique are the efficient and targeted coupling of toxic pharmaceutical amounts, but based on a reduced dose so that overall side effects are limited and the quality of life of the patient is maintained. The intention is to further expand this technology within “Skin-HUID” into a therapy through preclinical and clinical validation. A stimulation device with applicator will be developed that will be used for preclinical validation of the treatment. The consortium has now developed the prototype of the simulation device and placed it with the VIB and the UA. Based on the results of the first tests, the prototype was further optimised for pre-clinical validation. In parallel with preclinical developments, the preparation process of the medicinal product annexin A5-ETA is made suitable for production according to the guidelines of the European Medicines Agency (EMA). This is essential for clinical validation. Production according to these guidelines requires a special facility, the Clean Room. Basic Pharma has started the construction of a Clean Room with the production infrastructure with which the drug will be produced. The Clean Room facility was completed in the 3 rd quarter of 2018 and tested by an independent party and approved. The fermentor will be delivered in Q2 2019. Basic Pharma’s internal QA department has approved the Cleanroom with GMP production facility.

Achievements (NL):

Kanker is één van de meeste bedreigende ziektes van deze eeuw met jaarlijks wereldwijd 8 miljoen doden. De complexiteit van kanker maakt dat deze ziekte enkel succesvol behandeld kan worden door innovatie en vertaling van kennis naar nieuwe geneesmiddelen. Onder leiding van Universiteit Maastricht (UM) streven Universiteit Antwerpen (UA), Basic Pharma Technologies, MosaMedix en VIB ernaar een antwoord te bieden op de specifieke uitdagingen van huidkanker. Vanuit Euregional PACT, een virtueel onderzoekslaboratorium dat tot stand kwam via het vorige Interreg-programma, zijn reeds een aantal medische basistechnologieën op academisch niveau ontwikkeld. Eén van die technologieën is het Annexine-A5 gebaseerde platform voor Target Drug Delivery. Het omvat een gerichte toediening van medicijnen via elektrische of hyperthermische stimulatie die stress op de cellen zet. Voordelen van deze techniek zijn het efficiënt en doelgericht inkoppelen van toxische farmaceutische hoeveelheden, maar op basis van een verminderde dosis zodat algemene bijwerkingen beperkt blijven en de levenskwaliteit van de patiënt gehandhaafd blijft. De bedoeling is om deze technologie binnen ‘SKiN-HUID’ verder uit te spinnen tot een therapie via preklinische en klinische validatie. Er zal een stimulatietoestel met applicator ontwikkeld worden dat ingezet wordt voor een preklinische validatie van de behandeling. Het consortium heeft inmiddels het prototype van het simulatietoestel ontwikkeld en bij het VIB en de UA geplaatst. Aan de hand van de resultaten van de eerste testen is het prototype verder geoptimaliseerd voor de preklinische validatie. Parallel aan de preklinische ontwikkelingen wordt het bereidingsproces van het geneesmiddel annexine A5-ETA geschikt gemaakt voor de productie volgens de richtlijnen van het Europese Agentschap voor Medicijnen (EMA). Dit is essentieel voor de klinische validatie. Productie volgens deze richtlijnen vergt een speciale faciliteit, de Clean Room. Basic Pharma is gestart met de bouw van een Clean Room met de productieinfrastructuur waarmee het geneesmiddel geproduceerd zal worden. De Clean Room faciliteit is in het 3e kwartaal van 2018 gereed gekomen en getest door een onafhankelijke partij en goedgekeurd. De fermentor zal in het 2e kwartaal 2019 geleverd worden. De interne QA afdeling van Basic Pharma heeft de Cleanroom met GMP-productie faciliteit goedgekeurd.

Website: http://www.grensregio.eu/

Thematic information

Health and social services

Specific Objective: Innovation of products/ services/ applications/ processes in the form of industrial research and experimental development through the cooperation among enterprises as well as among enterprises, R&I centers and universities

Thematic Objective: (01) strengthening research, technological development and innovation by:

Investment Priority:

(01b) promoting business investment in R&I, developing links and synergies between enterprises, research and development centres and the higher education sector, in particular promoting investment in product and service development, technology transfer, social innovation, eco-innovation, public service applications, demand stimulation, networking, clusters and open innovation through smart specialisation, and supporting technological and applied research, pilot lines, early product validation actions, advanced manufacturing capabilities and first production, in particular in key enabling technologies and diffusion of general purpose technologies

Partners (5)

Lead Partner: Universiteit Maastricht

Address: Universiteitssingel 50, 6229ER Maastricht, Netherlands

Legal status: public

Total budget: EUR 1 084 777.06

ERDF budget: EUR 542 388.53

VIB

Name: VIB

Address: Rijvisschestraat 120, 9052 Zwijnaarde, Belgium

Legal status: private

Total budget: EUR 582 000.55

ERDF budget: EUR 291 000.27

Universiteit Antwerpen

Name: Universiteit Antwerpen

Address: Prinsstraat 13, 2000 Antwerpen, Belgium

Legal status: public

Total budget: EUR 356 997.25

ERDF budget: EUR 178 498.63

MosaMedix

Name: MosaMedix

Address: Oude Rijksweg Zuid 19-21, 6114RC Susteren, Netherlands

Legal status: private

Total budget: EUR 153 400.00

ERDF budget: EUR 76 700.00

Basic Pharma Technologies BV

Name: Basic Pharma Technologies BV

Address: Burgemeester Lemmensstraat 352, 6163JT Geleen, Netherlands

Legal status: private

Total budget: EUR 833 804.00

ERDF budget: EUR 416 902.00

Partners map

Partners and Projects info

VIB

SKiN-HUID

Partners and Projects info

Universiteit Maastricht

SKiN-HUID

Partners and Projects info

Universiteit Antwerpen

SKiN-HUID

Partners and Projects info

MosaMedix

SKiN-HUID

Partners and Projects info

Basic Pharma Technologies BV

SKiN-HUID

Lead partner

Project partner

Summary

Project name (EN): SKiN-HUID

Project acronym: SKiN-HUID

Project start date: 2016-09-01

Project end date: 2019-08-31

Project status: closed

Total budget/expenditure: EUR 3 010 978.86

Total EU funding (amount): EUR 1 505 489.43

Co-financing sources:

ERDF: Amount, EUR 1 505 489.43.

Information regarding the data in keep.eu on the programme financing this project

Financing programme

2014 - 2020 INTERREG V-A Belgium - The Netherlands (Vlaanderen - Nederland)

Last month that data in keep.eu was retrieved from the Programme's website or received from the Programme

2022-08-25

No. of projects in keep.eu / Total no. of projects (% of projects in keep.eu)

94 / 94 (100%)

No. of project partnerships in keep.eu / Total no. of project partnerships (% of project partnerships in keep.eu)

1 226 / 1 226 (100%)

Notes on the data

Information provided by the Programme. Achievements were retrieved by Interact from the Programme website (http://www.grensregio.eu/en), or a website directly linked from it, on 2021-11-04, 2023-01-12 and 2024-02-24.

Fields project name, description and achievement (from 61 projects) translated from Dutch into English using the European Commission's eTranslation machine translation service.

The projects which fields include an eTranslation English text are the ones with the following acronyms: Beton naar hoogwaardig beton, Biomat, Blijf aan Z, Circulair onderhoud, CO2 voor energieopslag (EnOp), De blauwe keten, De Lerende Euregio Scheldemond, Deeldezon, Fotonica pilootlijnen, Grensinfovoorziening VL-NL, Grenspark Groot Saeftinghe, Grenzeloos Biobased Onderwijs, Intelligenter Fruit Telen, Lerend Netwerk Biobouwers, Leve(n) de Bodem, LogistiekLerenZonderGrenzen, Meer natuur voor pittig fruit, Praktijklab Corrosie&Isolatie, REVIVAK (Revival vakmanschap), Entomospeed, PV OpMaat, ENLEB, Smart tooling procesindustrie, 2B Connect, Accelerate³, AQUA-VLAN 2, BIO – HarT, CrossCare, IMPAKT!, GIST, Educavia, CrossRoads 2, IMPROVED, i-4-1-Health, DEMI MORE, Meer natuur voor pittig fruit, Train4SmartServices, Link2innovate, Nano4Sports, See2Do!, eco2eco, GrasGoed – NGAG, Growing a Green Future, SKiN-HUID, Smartsediment, Smart Services Bridge, Trans Tech Diagnostics, Triple F (Food From Food), ZORO, ZULU, Glitch, Intelligenter Fruit Telen, I-QUA, PASSAnT, RHEDCOOP, TERTS, Waterstofregio 2.0 and Werkinzicht.

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SKiN-HUID

Description

Thematic information

Partners (5)

Partners map

Summary

Information regarding the data in keep.eu on the programme financing this project

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